Diaryl peptidic used as inhibitors of NS3 serine protease Hepatitis C virus.

A compound, including enantiomers, stereoisomers, rotamers and tautomers of said compound and salts, solvates or pharmaceutically acceptable derivatives thereof, said compound having the general structure shown in Formula I: ** ** see formula in which X and Y they are independently selected from the moieties: alkyl, alkylaryl, heteroalkyl, heteroaryl, arylheteroaryl, heteroaryl alkyl, cycloalkyl, alkyl ether, alkylaryl ether, aryl ether, alkyl amino, aryl amino, alkylaryl amino, alkylthio, alkyl- aryl thio, aryl thio, alkyl sulfone, alkylaryl sulfone, sulfone aryl, alkyl-alkyl sulfoxide, alkylaryl sulfoxide, alkyl amide, alkylaryl amide, aryl amide, sulfonamide, alkyl-aryl sulfonamide, aryl sulfonamide, alkyl urea, alkyl aryl urea, aryl urea, alkyl carbamate, aryl carbamate, alkyl, aryl carbamate, alkyl-hydrazide, alkylaryl hydrazide, alkyl hydroxamide, alkylaryl hydroxamide, alkyl sulfonyl, aryl sulfon yl, heteroalkyl sulfonyl, heteroaryl sulfonyl, alkyl carbonyl, aryl carbonyl, heteroalkyl carbonyl, heteroaryl carbonyl, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl, heteroarylaminocarbonyl or a combination thereof, with the proviso that X and Y may be optionally substituted additionally with X 11 or X 12; X 11 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, alkylaryl, arylalkyl, heteroaryl, alkylheteroaryl, or heteroarylalkyl, with the proviso that X 11 may be optionally further substituted with X 12; X 12 is hydroxy, alkoxy, aryloxy, thio, alkylthio, arylthio, amino, alkylamino, arylamino, alkylsulfonyl, arylsulfonyl, alkylsulfonamido, arylsulfonamido, carboxy, carbalkoxy, carboxamido, alkoxycarbonylamino, alkoxycarbonyloxy, alkylureido, arylureido, halogen, cyano or nitro, with provided that said alkyl, alkoxy and aryl may be optionally further substituted with independently selected residues X12; W may be present or absent, and if W is present, W is selected from C = O, C = S or SO2; Q may be present or absent, and when Q is present, Q is CH, N, P, (CH2) p, (CHR) p, (CRR ') p, O, NR, S or SO 2; and when Q is absent, M is also absent, and A is directly linked to X; A is O, CH 2, (CHR) p, (CHR-CHR ') p, (CRR') p, NR, S, SO 2 or a bond; U is selected from N or CH; E is CH, N or CR, or a double bond towards A, L or G; G may be present or absent, and when G is present, G is (CH2) p, (CHR) p (CRR ') p; and when G is absent, J is present and E is directly connected to the carbon atom to which was connected G; J may be absent or present, and when J is present, J is (CH 2) p, (CHR) p (CRR ') p, SO 2, NH, NR or O; and when J is absent, G is present and L is directly linked to nitrogen; L may be present or absent, and when L is present, L is CH, CR, O, S or NR; and when L is absent, then M may be absent or present, and if M is present with L being absent, then M is directly and independently linked to E, and J is directly and independently linked to E; M may be present or absent, and when M is present, M is O, NR, S, SO2, (CH2) p, (CHR) p, (CHR-CHR ') p (CRR') p; p is a number from 0 to 6; R and R 'are independently selected from the group consisting of H; C1-C10 alkyl; C2-C10 alkenyl; C3-C8cycloalkyl; C3-C8 heterocycloalkyl, alkoxy, aryloxy, alkylthio, arylthio, amino, amido, cyano, nitro; (Cycloalkyl) alkyl and (heterocycloalkyl) alkyl, wherein said cycloalkyl is made of three to eight carbon atoms and zero to six oxygen, nitrogen, sulfur or phosphorus, and said alkyl having one to six carbon atoms; aryl; heteroaryl; alkyl aryl and alkyl-heteroaryl; where said alkyl, heteroalkyl, alkenyl, heteroalkenyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl may be optionally substituted, referring said term "substituted" to optional and suitable substitution with one or more moieties selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, heterocyclyl, halogen, hydroxy, thio, alkoxy, aryloxy, alkylthio, arylthio, amino, amido, cyano, nitro, sulfonamido; and P1a, P1b, P1 'and P3 are independently selected from: H, C1-C10 straight or branched chain alkyl, C2-C10 straight or branched chain and cycloalkyl C3-C8 cycloalkyl, C3-C8; (Cycloalkyl) alkyl or (heterocyclyl) alkyl, wherein said cycloalkyl having 3 to 8 carbon atoms and zero to 6 oxygen, nitrogen, sulfur or phosphorus, said alkyl having 1 to 6 carbon atoms; aryl, heteroaryl, arylalkyl or heteroarylalkyl, wherein said alkyl of 1 to 6 carbon atoms; where said alkyl, alkenyl, cycloalkyl, heterocyclyl, (cycloalkyl) alkyl and (heterocyclyl) alkyl may be optionally substituted with R '', and further wherein said P 1a and P 1b may optionally be joined together to form a ring spirocyclic or spiroheterocyclic containing said spirocyclic or spiroheterocyclic ring zero to six oxygen, nitrogen, sulfur or phosphorus, and may be additionally optionally substituted with R ''; R '' is a hydroxy, alkoxy, aryloxy, thio, alkylthio, arylthio, amino, alkylamino, arylamino, alkylsulfonyl, arylsulfonyl, alkylsulfonamido, arylsulfonamido, carboxy, carbalkoxy, carboxamido, alkoxycarbonylamino, alkoxycarbonyloxy, alkylureido, arylureido, halogen, cyano or nitro, with the proviso that the alkyl, alkoxy, and aryl may be optionally further substituted with independently selected from R '' moieties; Z is O, NH or NR '' ''; R '' '' is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, alkylaryl, arylalkyl, heteroaryl, alkylheteroaryl, or heteroarylalkyl, with the proviso that R '' can be optionally further substituted with R ''; Ar 1 and Ar 2 are independently selected from phenyl; 2-pyridyl, 3-pyridyl, 4-pyridyl or their corresponding N-oxides; 2-thiophenyl; 3-thiophenyl; 2-furanyl; 3-furanyl; 2-pyrrolyl; 3-pyrrolyl; 2-imidazolyl; 3 (4) -imidazolyl; 3- (1,2,4-triazolyl); 5-tetrazolyl; 2-thiazolyl; 4-thiazolyl; 2-oxazolyl; or 4-oxazolyl; each of which or both may be optionally substituted with R 1; R 1 is H, halogen, cyano, nitro, CF3, Si (alkyl) 3, lower alkyl straight or branched chain alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, alkylaryl, arylalkyl, heteroaryl, hydroxy, alkoxy, aryloxy, alkoxycarbonyloxy, (alkylamino) carbonyloxy, mercapto, alkylthio, arylthio, alkylsulfinyl, heterocyclylsulfinyl, arylsulfinyl, heteroarylsulfinyl, alkylsulfonyl, heterocyclylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylcarbonyl, arylcarbonyl, carboxy, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl, amino, alkylamino , arylamino, alkylsulfonamide, arylsulfonamide, alkoxycarbonylamino, alkylureide or arylureide; P 4 is H, linear or branched, arylalkyl or aryl; and R2 'is H, cyano, CF3, lower alkyl straight or branched chain alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, alkylaryl, arylalkyl, heteroaryl, alkylsulfonyl, arylsulfonyl, carboxy, alkoxycarbonyl, aryloxycarbonyl, alkylaminocarbonyl, (allylamino) carbonyl or arylaminocarbonyl.