Association between vitamin D serum levels and inflammatory markers in patients on hemodialysis

INTRODUCTION The relationship between 25-OH-vitamin D and the immune system in patients with chronic kidney disease is a subject of attention. Objectives To assess the prevalence of vitamin D deficiency in patients on hemodialysis and to investigate the association between vitamin D, ultra-sensitive C-reactive protein (US-CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). METHOD Cross-sectional study of 80 patients on hemodialysis, divided into two groups: a serum 25-OH-vitamin D level < 20 ng/mL was considered to be vitamin D deficiency and a serum level ≥ 20 ng/mL was regarded as normal. The relationship between the parameters was defined with Spearman's correlation analysis. RESULTS 40 % of the patients had vitamin D deficiency. There were significant differences between groups in US-CRP (p = 0.047), NLR (p = 0.039), PLR (p = 0.042) and treatment with vitamin D analogues (p = 0.022). Vitamin D had a significant negative correlation with US-CRP (p = 0.026), NLR (p = 0.013) and PLR (p = 0.022). CONCLUSIONS The prevalence of vitamin D deficiency was 40 %. The values of US-CRP, NLR and PLR were significantly higher in the presence of vitamin D deficiency. A significant inverse correlation was found between vitamin D levels and US-CRP, NLR and PLR. INTRODUCCION La relacion entre 25-OH-vitamina D y el sistema inmune en pacientes con enfermedad renal cronica es objeto de atencion. OBJETIVOS Evaluar la prevalencia de la deficiencia de vitamina D en pacientes en hemodialisis e investigar la asociacion entre la vitamina D y proteina C reactiva ultrasensible (PCRus), indice neutrofilo-linfocito (INL) e indice plaqueta-linfocito (IPL). METODO Estudio transversal de 80 pacientes en hemodialisis, divididos en dos grupos: un nivel serico de 25-OH-vitamina D < 20 ng/mL se considero como deficiencia de vitamina D y ≥ 20 ng/mL, como normal. Con el analisis de correlacion de Spearman se definio la relacion entre los parametros. RESULTADOS 40 % de los pacientes presento deficiencia de vitamina D. Hubo diferencias significativas entre los grupos en PCRus (p = 0.047), INL (p = 0.039), IPL (p = 0.042) y tratamiento con analogos de vitamina D (p = 0.022). La vitamina D tuvo una correlacion negativa significativa con PCRus (p = 0.026), INL (p = 0.013) e IPL (p = 0.022). CONCLUSIONES La deficiencia de vitamina D fue de 40 %. Los niveles de PCRus, INL e IPL fueron significativamente mas altos ante deficiencia de vitamina D. Se encontro correlacion inversa significativa entre vitamina D y PCRus, INL e IPL.