Combination Therapy with the Antiandrogen Flutamide and the LHRH Agonist [D-Trp6, des-Gly-NH2 10]LHRH Ethylamide in Prostate Cancer: Rationale and 5-Year Clinical Experience

Man is unique among species in having adrenals which secrete large amounts of precursor steroids which are converted into active androgens in the prostate and other peripheral tissues (Acevedo and Goldzieher, 1965; Harper et al., 1974; Cameron et al., 1966; Voigt and Bartsch, 1986).