The role of PGE2 EP4 receptors in the regulation of endothelial barrier function

Background Prostaglandin E2 plays a crucial role in inflammation, including pain, fever and tumorigenesis. Inflammatory cells, fibroblasts and epithelium are the main source of PGE2 throughout an immune response. There are four known receptors for PGE2, E type prostanoid receptors 1–4 (EP1,2,3,4). According to recent reports, the EP4 receptor seems to be a potential target of therapeutic treatment for attenuating inflammation as well as increased endothelial permeability.