Fruit of Hovenia dulcis Thunb. induces non-shivering thermogenesis through mitochondrial biogenesis and activation by SIRT1 in high fat diet-fed obese mice and primary cultured brown adipocytes

Brown adipocytes, which contain abundant mitochondria, use stored energy as fuel during a process called non-shivering thermogenesis. Thus, the pharmacological activation of non-shivering thermogen...