Spontaneous Pancreatic Islet Amyloidosis in a Greater White-nosed Guenon (Ceropithecus nictitans)

Pancreatic islet amyloidosis from a 15-year-old female greater white-nosed guenon is described. The monkey had been kept in an indoor exhibition facility at the Seoul Grand Park, Korea, and died 2 days after development of anorexia and lethargy. Histologically, amorphic homogeneous eosinophilic, hyalinized material was found deposited in the pancreatic islets and was positive for Congo red stain. The deposits were positive to amyloid A protein and P component by immunohistochemistry. Additionally, glucosuria and ketonuria were detected.