A COMPARATIVE STUDY BETWEEN INTRAVENOUS DEXMEDETOMIDINE AND 50% MAGNESIUM SULFATE IN ATTENUATION OF CARDIOVASCULAR RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION.

INTRODUCTION : Hypertension and tachycardia subsequent to tracheal intubation have been well documented. In susceptible patients it can cause increase in perioperative morbidity and mortality. Many agents have been used to attenuate these undesirable hemodynamic responses to laryngoscopy and intubation with varying success.  Dexmedetomidine increases the hemodynamic stability by altering the stress induced sympatho-adrenal responses to laryngoscopy and intubation during surgery and emergence from anesthesia. On the other hand, magnesium sulfate can significantly attenuate the release of catecholamines at the time of laryngoscopy and tracheal intubation. AIM: The present study was aimed to compare Inj, Dexmedetomidine 1µg/kg and Magnesium sulfate 50mg/kg in attenuation of cardiovascular response to laryngoscopy and intubation. METHODS: A randomized prospective study was conducted in Silchar Medical College and Hospital, Silchar, Assam after obtaining Institutional Ethical Committee clearance and written informed consent from the patients. INCLUSION CRITERIA: Patients between age 18-60 years , of both sexes , ASA grade II p-value<0.05 was considered significant and <0.001 as highly significant. RESULTS: There was no significant difference between the groups with regard to demographic variables. The mean fall in HR, SBP, DBP and MAP values at 2 and 5 minutes of intubation were statistically highly significant (p=0.000) in group A as compared to group B. DISCUSSION: The results were compared with various other similar studies which had analyzed the effect of dexmedetomidine and magnesium sulfate for attenuation of cardiovascular response during laryngoscopy and intubation and our results correlated with those studies.