ACCELERATED STABILITY TESTING OF BETAMETHASONE DIPROPIONATE NANOEMULSION Research Article
2012
The nanoemulsion formulation containing Betamethasone dipropionate (BD) was prepared by spontaneous emulsification method. These were characterized by droplet size, viscosity and refractive index. Stability studies were performed for a period of 3-months. Droplet size, viscosity and refractive index were determined every month for three months. Shelf-life of nanoemulsion formulation was also determined after performing the accelerated stability testing. It was found that the droplet size, viscosity and refractive index were slightly increased at refrigerator (4oC) and room temperature (25oC) during 3-months of storage period. However, the changes in these parameters were not statistically significant (p ≥0.05). The shelf-life of optimized nanoemulsion formulation was found to be 2.66 years at room temperature. These results indicated that the stability (physical and chemical) of BD was enhanced in nanoemulsion formulation.
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