Synthesis of 4,4′-Disubstituted Azepines via Ring-Closing Metathesis Reaction and Asymmetric Arylation of Lactones

The syntheses of the title compounds were accomplished via ail original sequence of reactions including the ring-closing metathesis of co-dienes by using the second-generation Grubbs' catalyst. The chiral diene precursors are available in racemic or optically enriched form from the corresponding alpha,alpha'-disubstituted lactones derivatives.