An Overview of the Recent Developments in Analytical Methodologies for Determination of Proton Pump Inhibitors in Bulk Drugs, Pharmaceuticals and Biological Matrices

An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination of proton pump inhibitorsin bulk drugs, formulations and biological fluids have been reviewed. This review covers the time period from 1990 to 2011 during which 80 analytical methods including all types of spectrophotmetric and chromatographic techniques were reported. HPLC with UV detection was found to be the technique of choice for many workers and more than 50 methods were based on LC and UV. A critical analysis of the reported data has been carried out and the present state-of-art of the analytical techniques for determination of omeprazole, esomeprazole, pantoprazole, rabeprazole, dexrabeprazole, tenatoprazole, lansoprazole and dexlansoprazole has been discussed.