THE WARBURG EFFECT IN THE HEART: INCREASED GLUCOSE METABOLISM DRIVES CARDIOMYOCYTE HYPERTROPHY IN RESPONSE TO ADRENERGIC STIMULATION

The Warburg effect in cancer cells entails enhanced lactate production from glucose in the presence of oxygen. We have recently discovered footprints of the Warburg effect in the failing human heart and that metabolic remodeling precedes structural remodeling. Our aim was to test the hypothesis that