Impact of lactate dehydrogenase (LDH) and absolute lymphocyte count (ALC) on outcome of previously treated patients with malignant pleural mesothelioma (MPM) receiving chemotherapy (CT) with or without NGR-hTNF in the phase 3 trial NGR015.

Vanesa Gregorc,Maria Grazia Viganò,Alessandra Bulotta,Giovanni Citterio,Giovanna Petrella,Elena Brioschi,Monika Ducceschi,Luca Gianni,Scialini Colombi,G. Rossoni,Giulia Salini,Emma Redaelli,A. Lambiase,Claudio Bordignon

Impact of lactate dehydrogenase (LDH) and absolute lymphocyte count (ALC) on outcome of previously treated patients with malignant pleural mesothelioma (MPM) receiving chemotherapy (CT) with or without NGR-hTNF in the phase 3 trial NGR015.

2016

Vanesa Gregorc
Maria Grazia Viganò
Alessandra Bulotta
Giovanni Citterio
Giovanna Petrella
Elena Brioschi
Monika Ducceschi
Luca Gianni
Scialini Colombi
G. Rossoni
Giulia Salini
Emma Redaelli
A. Lambiase
Claudio Bordignon

e20075Background: NGR-hTNF selectively binds to CD13-expressing blood vessels and improves intratumor T-lymphocyte infiltration and CT uptake. CD13 expression is upregulated by tumor hypoxia/angiog...

Keywords:

Absolute lymphocyte count
Mesothelioma
Pathology
Lactate dehydrogenase
NGR-hTNF
Chemotherapy
Medicine
Tumor hypoxia
previously treated
pleural mesothelioma
Downregulation and upregulation

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