Chemical Studies of 10-Deacetyl Baccatin III. Hemisynthesis of Taxol Derivatives.

Abstract The chemical reactivities of 10-deacetyl baccatin III and of baccatin III, two natural products extracted from Taxus baccata L., were studied with the aim of synthesizing taxol analogues having a modified side-chain at C-13, thereby restoring good binding to tubulin.