Oral administration of linoleic acid induces new vessel formation and improves skin wound healing in diabetic rats

Hosana G. Rodrigues,Marco Aurélio Ramirez Vinolo,Fabio Takeo Sato,Juliana Magdalon,Carolina M. C. Kühl,Ana S. Yamagata,Ana Flávia Marçal Pessoa,Gabriella Malheiros,Marinilce Fagundes dos Santos,Camila Lima,Sandra Helena Poliselli Farsky,Niels Olsen Saraiva Câmara,María Rosa Williner,Claudio A. Bernal,Philip C. Calder,Rui Curi

Oral administration of linoleic acid induces new vessel formation and improves skin wound healing in diabetic rats

2016

Hosana G. Rodrigues
Marco Aurélio Ramirez Vinolo
Fabio Takeo Sato
Juliana Magdalon
Carolina M. C. Kühl
Ana S. Yamagata
Ana Flávia Marçal Pessoa
Gabriella Malheiros
Marinilce Fagundes dos Santos
Camila Lima
Sandra Helena Poliselli Farsky
Niels Olsen Saraiva Câmara
María Rosa Williner
Claudio A. Bernal
Philip C. Calder
Rui Curi

Introduction Impaired wound healing has been widely reported in diabetes. Linoleic acid (LA) accelerates the skin wound healing process in non-diabetic rats. However, LA has not been tested in diabetic animals.

Keywords:

Transcription factor
Oral administration
Linoleic acid
Impaired wound healing
Pharmacology
Wound healing
Surgery
Medicine
Diabetes mellitus
Messenger RNA
Vascular endothelial growth factor A
Leukotriene B4
Cell migration
Growth factor
Inflammation
Angiogenesis

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