Relationship between ABO and Secretor genotype with plasma levels of factor VIII and von Willebrand factor in thrombosis patients and control individuals.

Several acquired conditions are associated with an increased risk of venous thrombosis, e.g. immobilization, trauma, surgery, malignancies, pregnancy and use of oral contraceptives, as well as the anti-phospholipid antibody syndrome. Well-known hereditary risk factors for venous thrombosis are, for example, the deficiency of antithrombin, protein C or protein S, dysfibrinogenemia, the factor V Leiden and the prothrombin G20210A mutation. Elevated plasma levels of procoagulants (e.g. factor VIII; FVIII) may also be associated with an increased risk for venous thrombosis. The risk associated with hyperhomocysteinaemia is attributable to a congenital enzyme deficiency in combination with an alimentary deficit. In the past, more attention has been given to other congenital conditions, associated with an increased risk for venous thrombosis, such as certain ABO blood groups (Lane