ESTUDIO FITOQUÍMICO DE LAS HOJAS DE BOWDICHIA VIRGILIOIDES

Bowdichia virgilioides, is a medicinal plant used by the Tacana ethnic group. The leaves of this tree were collected, during the dry season, in the Abel Iturralde province, Bolivia. The dry and pulverized leaves were macerated with methilenechloride, and the raw extract did not show activity at 10μg/mL, against Plasmodium falciparum (strand F32, sensible to chloroquine). Chromatographic studies of the crude extract and spectroscopical analysis of the isolated substances allowed us to identify: Lupeol (1), Lupenone (2), β-sitosterol (3), stigmasterol (4) and β-amyrine (5), as the main triterpenes components along with non identified fatty acids. RESUMEN Bowdichia virgilioides, es una planta medicinal utilizada por la etnia Tacana, las hojas de este arbol fueron colectadas, en epoca seca, en la Prov. Abel Iturralde, Bolivia. Las hojas secas y pulverizadas fueron sometidas a maceracion con diclorometano y el extracto crudo no presento actividad antipaludica a dosis de 10μg/mL, frente a Plasmodium falciparum (cepa F32, sensible a la cloroquina). Estudios cromatograficos del extracto crudo y analisis espectroscopicos de las sustancias aisladas nos han permitido identificar: Lupeol (1), Lupenona (2), β-sitosterol (3), estigmasterol (4) y βamirina (5), como los principales componentes triterpenicos acompanados de acidos grasos no identificados.