Clinical and Molecular Anatomy of Gastrointestinal Stromal Tumors (GIST)

Introductionnbsp Gastrointestinal stromal tumors GISTs are rare and fall into the category of non-epithelial tumors of the gastrointestinal tract , involving the stomach at a higher percentage (70 %). The purpose of this study , through a retrospective analysis of the observed cases , is to obtain data on the incidence , survival curve identification of prognostic and predictive parameters .The goal is to collect data concerning the natural history of GIST , 65% of patients were female, 35% male , mean age 64 years. Metastatic disease was assessed by cd171. In this study, n 11 (65 %) cases were L1 ( cd171 ) positive for smooth muscle tumors . Of which 8 with headquarters in the stomach, ileum en 3 . Investigations have been performed immunohistochemistry with CD117 , CD99 , ema .nbsp all enrolled patients tested positive for CD117 .Discussion Thread What are the prognostic factors of GiST is still a matter of debate, but the consensus conference (NIH) in 2001 defined BETHESTHA n 2 parameters which are: the size and mitotic index of 50 HP for the lesions found were reported as accidental the size ranged lt 10mm to gt 50mm . . . The study carried out shows that the markers are the key to the histological diagnosis of GIST Malignancies in GIST have introduced anti-angiogenic therapy with administration of sunitinib at a dose of 50mg/die for 4 weeks every 6 . For the purpose of inhibiting tumor growth with a time of disease-free interval longer. It is evident that in the histological diagnosis of GIST are inserted reporting the results of molecular biology with immunohistochemical markers , in combination with mitotic index , and tumor size in order to define a completenbsp risks MTS nbsp