Studies on pathogen of neonate navel infection and its drug resistance

Objective To understand and identify the category of pathogen of neonate navel infection and its distribution and drug resistance to antibiotics,and to provide guidances on clinic drug administration.Methods Bacteria culture,appraisal and antibiotic sensitivity trials for infected navel excretion of 140 newborn cases were conducted from January 2001 to October 2005,and the experiments strictly followed the update standards of NCCLS.Results The group of neonate navel infection is mainly due to gram-positive bacteria,which accounts for 56.7%.The principal pathogens are S.aureus,Staphylococcus epidermitis,and Escherichia coli.Hospital infection is characterized by coagulase-negative staphylococci epidermitis,which takes up 30.77%,and social acquired infection is largely caused by coagulase-positive S.aureus,it makes for 36.49%.The principal pathogens show multiple resistances to conventional antibiotics.The drug resistance of Escherichia coli and Enterobacter to Cefpodoxime proxetil,qunolones and aminoglycosides and phosphomycin decreases in turn.Staphylococcus is sensitive to Vancomycin However,1 strain of Staphylococcus epidermidis resistant to vancomycin is discovered.Escherichia coli and enterobacter are sensitive to imipenem.Conclusion It is of significance in attaching much importance to and strengthening monitoring and control of hospital infection at Neonate departments and in guiding rational clinic antibiotics administration strictly based upon the microorganism testing results.