Synthesis of C6A-to-C6A and C3A-to-C3A diamide linked γ-cyclodextrin dimers

Abstract The syntheses of three new diamide-linked γ-cyclodextrin dimers joined by substitution at either a glucopyranose C6 A or C3 A carbon are reported. The syntheses involve the reaction of either C6 A or C3 A amino-substituted γ-cyclodextrin with bis(4-nitrophenyl)succinate to form succinamide linked γ-cyclodextrin dimers or reaction of C6 A azide-substituted γ-cyclodextrin with carbon dioxide to form a urea linked γ-cyclodextrin dimer.