Is neurogenesis reparative after status epilepticus

Neurogenesis persists in the hippocampal dentate gyrus of mammals, including human and nonhuman primates, throughout life (Altman and Das, 1965; Cameron et al., 1993; Kuhn et al., 1996; Eriksson et al., 1998; Gould et al., 1999; Kornack and Rakic, 2001). Neural stemlike cells reside in the subgranular zone (SGZ) at the border of the hilus and DGC layer (Seri et al., 2001; Filippov et al., 2003), where they generate neuroblasts that migrate into the layer and differentiate into granule neurons (Cameron et al., 1993; Kuhn et al., 1996). Adult-born dentate granule cells (DGCs) send axonal projections to appropriate targets (Stanfield and Trice, 1988; Markakis and Gage, 1999; van Praag et al., 2002) and acquire electrophysiological characteristics of mature DGCs (van Praag et al., 2002; Wadiche et al., 2005; Ge et al., 2006). Although the precise function is unknown, evidence implicates DGC neurogenesis in certain forms of hippocampus-dependent learning and memory (reviewed in Doetsch and Hen [2005]).