Comparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China
2021
Objective This prospective study aimed to investigate the prognosis and rehabilitation of patients
with recurrent depression and first episode depression after acute treatment in China.
Methods A total of 434 patients with first-episode or recurrent depression who received acute
treatment respectively from sixteen hospitals in thirteen cities in China were enrolled
in this prospective study. All patients were followed up for 6 months after acute
treatment. The following data were collected at baseline period and 1, 3, and 6 months
after acute treatment: general information of patients, medication information and
patient’s condition changes, brief 16-item quick inventory of depressive symptomatology
self-report (QIDS-SR16), patient health questionnaire-15 (PHQ-15), quality of life
enjoyment and satisfaction questionnaire-short form (Q-LES-Q-SF), Sheehan disability
scale (SDS) and digit symbol substitution test (DSST).
Results During the baseline period, there was a significant difference in QIDS-SR16 between
recurrent patients and first-episode patients (p < 0.05), and there was no significant
difference in other indicators (p > 0.05). At one month after acute treatment, there
were significant differences in the total QIDS-SR16 score, the total Q-LES-SF score,
the social life score, and the family life/home responsibilities score of SDS in patients
with recurrent depression and first-episode depression (p < 0.05). At three months
after acute treatment, there were significant differences in the total Q-LES-SF score
and social life score of SDS in patients with recurrent depression and first-episode
depression (p < 0.05). At six months after acute treatment, there were significant
differences in the total QIDS-SR16 score, the social life score, and the total Q-LES-SF
score in patients with recurrent depression and first-episode depression (p < 0.05).
Compared with that data during the baseline period, the QIDS-SR16 scores and the SDS
scores of all patients decreased, and the Q-LES-SF scores of all patients gradually
increased as time went on during the consolidation period.
Conclusion The recurrent patients have more severe social function impairment, depressive symptoms,
and lower life quality than that of the first-episode depressed patients. Given the
negative impact of depressed symptom on recurrent patient, more attention should be
paid to the treatment of recurrent patient and recurrence prevention of first episode
patient.
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