Changes of acetylcholine, catecholamines and amino acid in mice brain following treatment with nuvacron and furadan

Abstract The effects of multiple intraperitoneal doses of Nuvacron (0.8 mg/kg) or Furadan (0.25 mg/kg) on the concentrations of brain neurtoranmitters in mice were studied. The following were measured: acetylcholine, acetylcholinesterase, gamma-aminobutyric acid, epinephrine, norepinephrine, dopamine and 5-hydroxytryptamine. These pesticides caused a significant decrease in acetylcholinesterase activity and a significant increase in acetylcholine, γ-amino-butyric acid, epinephrine, norepinephrine, dopamine and 5-hydroxy tryptamine concentrations. The increased concentrations of the neurotransmitters in mouse brain might be associated with CNS depressant action induced by the insecticides.