The influence of closaverm а and catosal on indicators of protein synthesizing functions of cows liver by experimental fasciolosis, sentsitized by atypical mycobacteria

The article contains the results of research the impact of Fasciolosis and mycobacteriosis,the indicators of protein synthesizing function of cows liver. Fasciola and mycobacteria inhibit protein synthesizing function of liver, as indicated by the reduction in their blood level of total protein and albumin fraction. The data indicate hepatotropic of the toxin F. Hepatica and mycobacteria, because namely liver serves as a support of dynamic substances equilibrium of blood plasma. Increasing the level of globulin in the blood serum of cows by association of fasciolosis and mycobacteriosis reflects the intensity of inflammatory processes in animal organism caused by infection of these diseases. Application of closaverm A and catosal to research cows promotes restoration protein synthesizing function of liver. It was found that after application to cows from the first research group for the treatment of closaverm A by 14 and 21 days of level of total protein in the blood serum was gradually increased, but did not reach physiological values. Applying both closaverm A and catosal, was set a slightly higher level of total protein, that at the 28th day of the experiment reached physiological values and therefore amounted to 70.30 ± 1.5 g/l. For the study the level of albumin in the blood of research group, which were used drugs combined, was set its increase already from 7 day of experiment. Significant increase of albumin level in the blood of experimental animals is seeing on the 14th day of the experiment, where appropriate it was within 41.90 ± 1.5 g/l. On the 28th day of the experiment the levels of globulin in the blood of experimental group of animals, which were used closaverm A and catosal, was lower by 11% compared to the control group of animals in specified period of the experiment. Cows treated with closaverm A, value of the coefficient A/T was gradually returned to normal. However, at the 28th day of the experiment has remained at 16% less than the initial values, taken before infestation. Application of closaverm A and catosal to experimental animals contributed to increasing the coefficient of A/T. So at 21st and 28th days of the experiment it was higher than in the control group of cows at 60 and 46%.