Effect of Vitamin B6 Deficiency on the Intestinal Absorption and Excretion of Oxalate in Rats

Northern India has a high incidence of stone disease and nearly 96% of these stones contain calcium oxalate1. Several reports have suggested that the primary cause of stone-formation is the hyper- absorption of oxalate2 due to the marginal nutritional deficiency of vitamin B6 3. In this study the effect of B6 deficiency on the intestinal absorption and the renal clearance of oxalate has been studied along with the mechanism of its transport.