The orexin/hypocretin system : physiology and pathophysiology

Part I. History History and Overview of Orexin/Hypocretin Research: From Orphan GPCR to Integrative Physiology Michihiro Mieda and Takeshi Sakurai Part II. Overview of the Orexin/Hypocretin Neuronal System Orexin and Orexin Receptors Takeshi Sakurai Orexin Projections and Localization of Orexin Receptors Jacob N. Marcus and Joel K. Elmquist Neuronal Responses to Hypocretin/Orexin Anthony N. van den Pol and Claudio Acuna-Goycolea Afferent System of Orexin Neurons Akihiro Yamanaka Part III. Assessment of Orexin/Hypocretin Functions in Tissue and Biological Fluids Hypocretin Measurements in the CSF, and Blood and Brain Tissue: Basic and Clinical Applications Seiji Nishino Hypocretin Receptor-Activated G Proteins Revealed by [35S]GTPgS Autoradiography Rene Bernard, Ralph Lydic, and Helen A. Baghdoyan Part IV. Physiology A. Orexin/Hypocretin System and Hypothalamic Function Orexin System and Feeding Behavior Takeshi Sakurai Orexins and the Autonomic Nervous System Tetsuro Shirasaka and Masamitsu Nakazato Neuroendocrine Role of the Orexins (Hypocretins) Shahrad Taheri The Orexin/Hypocretin System and Stress and Emotion Yoichi Ueta and Hiroaki Fujihara B. Orexins/Hypocretins and Sleep Regulation Hypocretin as a Wakefulness Regulatory Peptide Luis de Lecea and J. Gregor Sutcliffe Hypocretin/Orexin Tonus and Vigilance Control Yasushi Yoshida and Seiji Nishino Hypocretin System and Aminergic and Cholinergic Systems in the Control of Vigilance Krister S. Eriksson and Helmut L. Haas Orexin and Hypothalamic Control of Sleep and Waking Rodrigo A. Espana and Thomas E. Scammell Hypocretin/Orexin and Motor Function Jerome M. Siegel Part V. Pathophysiology:Narcolepsy and Orexin/Hypocretin Deficiency A. Orexin/Hypocretin Deficiency and Narcolepsy Overview of Human Narcolepsy Scott Fromherz and Emmanuel Mignot Canine Models of Narcolepsy Seiji Nishino Rodent Models of Human Narcolepsy-Cataplexy Michihiro Mieda and Masashi Yanagisawa B. Orexin/Hypocretin Deficiency in Human Narcolepsy and Other Conditions Hypocretin Deficiency in Human Narcolepsy: Mutation Screening, Neuropathology, and CSF Hypocretin-1 Level Patrice Bourgin, Jamie M. Zeitzer, and Emmanuel Mignot Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy Takashi Kanbayashi, Junko Arii, Hideaki Kondo, Tetsuo Shimizu, and Seiji Nishino Hypocretin Measures in Psychiatric Disorders Ronald M. Salomon Neuroendocrinology of Human Narcolepsy Gert Jan Lammers, Sebastiaan Overeem, and Hanno Pijl Narcolepsy and Autoimmunity Shahrad Taheri, Jose Paterno, Ling Lin, and Emmauel Mignot C. Treatment/Pharmacology Pharmacology of Orexin/Hypocretin Peptides and Small Molecules Stephen J. Perry, David A. Schwarz, and Richard A. Maki Rescue of Narcoleptic Orexin Neuron-Ablated Mice by Ectopic Overexpression of Orexin Peptides Michihiro Mieda, Jon T. Willie, and Takeshi Sakurai Hypocretin/Orexin Replacement Therapy in Hypocretin/Orexin-Deficient Narcolepsy: An Overview Nobuhiro Fujiki and Seiji Nishino Index