Effectiveness of Gnetum gnemon Peel Extract as an Antihyperuricemic in White Rats ( Rattus norvegicus )

Melinjo (gnetum gnemon) peel extract is believed to have potential as antihyperuricemic agent, however, in vivo assays have yet to be conducted to prove the antihyperuricemic activity. The objectives of this research were to analyze antihyperuricemic activity of melinjo peel extract in Sprague Dawley male white rat. A total of 24 rats were divided into 6 groups, which are normal, positive, and negative group, 70% ethanolic extract of melinjo peel dose 450 mg/kgBW (ET I) and dose 900 mg/kgBW (ET II), and water extract of melinjo peel dose 93.35 mg/kgBW (EA). The results show that antihyperuricemic potency of 70% ethanolic extract of melinjo peel (ET1 and ET2) were more effective than allopurinol dose 90 mg/kgBW with percentage decrease of 50% and 54%. Ethanol extract of melinjo peel was able to reduce uric acid levels to be in the range of normal values (<5 mg / dL). Body weight gain of rats given ethanol extract of melinjo peel dose 450 mg/kgBW had values that were close to the normal group. Melinjo peel extract contained flavonoid, tannins, saponin, and triterpenoid.