Preparation method of parecoxib sodium compounds and intermediates impurities, preparation method and application

The present invention provides a parecoxib sodium obtained after a control of the intermediate impurity. Specifically, it provides a method for preparing a parecoxib sodium compound and impurities, the intermediate preparation method and application. 3-methyl-4,5-diphenyl-4,5-dihydro-isoxazol-5-ol was prepared as parecoxib sodium intermediate 5-methyl-3,4-diphenyl-4 , 5-dihydro-5-ol isomer impurity, in quality control of parecoxib sodium preparation thereof, particularly not more than impurity level required for the 0.5% sodium parecoxib product quality is of great significance. The present invention is obtained by 3-methyl-4,5-dihydro-5-phenyl-4,5-ol, 5-methyl-3,4-this important two-phenyl-4, 4,5-dihydro-5-ol isomer impurity, and further subjected to the preparation and testing process, purification process of research on using 5-methyl-3,4-diphenyl-4, 4,5-dihydro-5-ol has important significance for the quality control process of the industrial production of raw materials.