Dissecting the expression landscape of genitourinary cancers.

573Background: Genitourinary (GU) cancers include bladder urothelial carcinoma (BCa), prostate cancer, kidney clear cell or papillary carcinoma, uterus endometrial carcinoma, ovarian cystadenocarcinoma and testicular germ cell tumors. Clinical data show a higher prevalence of GU cancers for men than women, suggesting significant molecular differences depending on sex regarding cancer development. This project aims at dissecting the expression landscape for all GU cancers and identify significant dysregulated genes between cancer and normal tissues specific either for men and women. The resulting data will serve a clinical application consisting in targeting novel molecular biomarkers detected in urine for GU cancers early diagnosis. Methods: Based on RNAseq data provided by The Cancer Genome Atlas, gene expression fold-change for 19,123 genes from cancer tissues and normal tissues was initially compared for each GU cancer. To ensure significant gene dysregulation, only genes showing a fold-change ≤ -log2(...