One-Pot Synthesis of Indolizine via 1,3-Dipolar Cycloaddition Using a Sub-equivalent Amount of K2Cr2O7 as an Efficient Oxidant under Base Free Conditions.

A one-pot method for synthesizing multi-substituted indolizines from α-halo-carbonyl compounds, pyridines and electron deficient alkenes was developed. A sub-equivalent amount of potassium dichromate was used as an oxidant under base free conditions. The transformation developed should be of economic efficiency.