Preliminary study on characteristics of NA genes and oseltamivir resistance in 2009 pandemic H1N1 influenza viruses in Fujian, China.

To investigate characteristics of NA genes and oseltamivir susceptibility of 2009 pandemic H1N1 influenza viruses in Fujian Province,twenty-three strains were randomly selected for detection.Fragments of NA genes were amplified by one-step RT-PCR and then were sequenced.Comparing with the A/California/07/2009(H1N1),alignment of nucleic acid sequences revealed a high homology of 98.1%.While the amino acid residuals at 275 remained histidine,indicating all of the 23 isolates were oseltamivir-sensitive.This observation suggests no oseltamivir-resistant strains has emerged in Fujian.However,continuous surveillance is necessary for control and prevention strategies of the ongoing pandemic.