Group A streptococcal M-protein specific antibodies and T-cells drive the pathology observed in the rat autoimmune valvulitis model

Suchandan Sikder,Georgina Price,Abdul Alim,Anil Gautam,Robert S Simpson,Catherine M. Rush,Brenda L. Govan,Natkunam Ketheesan

Group A streptococcal M-protein specific antibodies and T-cells drive the pathology observed in the rat autoimmune valvulitis model

2019

Suchandan Sikder
Georgina Price
Abdul Alim
Anil Gautam
Robert S Simpson
Catherine M. Rush
Brenda L. Govan
Natkunam Ketheesan

AbstractAcute rheumatic fever (ARF) and rheumatic heart disease (RHD) are autoimmune mediated diseases triggered by group A streptococcal (GAS) infections. Molecular mimicry between GAS M-proteins ...

Keywords:

Streptococcal M protein
Immunology
Group A
Antibody
Diabetes mellitus
Biology
Immunopathology
Adoptive cell transfer
Pathology
Myocarditis
Immune system
Molecular mimicry
Carditis
Pathogenesis

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