Blockade of Angiogenesis by Small Molecule Antagonists to Protease-Activated Receptor-1: Association with Endothelial Cell Growth Suppression and Induction of Apoptosis

This letter is in response to the report by Zania et al. ([2006][1]). The authors used in vitro (Matrigel) and in vivo (chick chorioallantoic membrane) models of angiogenesis to demonstrate that small molecule PAR1 antagonists, SCH79797 and RWJ56110, block formation of new blood vessels through