Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis

Pamela J. Hornby,Philip R. Cooper,Connie Kliwinski,Edwin Ragwan,John R. Mabus,Benjamin Harman,Suzanne E. Thompson,Amanda L. Kauffman,Zhengyin Yan,Susan H. Tam,Haimanti Dorai,Gordon Powers,Jill Giles-Komar

Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis

2014

Pamela J. Hornby
Philip R. Cooper
Connie Kliwinski
Edwin Ragwan
John R. Mabus
Benjamin Harman
Suzanne E. Thompson
Amanda L. Kauffman
Zhengyin Yan
Susan H. Tam
Haimanti Dorai
Gordon Powers
Jill Giles-Komar

Purpose To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) in adult primate intestine to determine whether this is a means for oral delivery of monoclonal antibodies (mAbs).

Keywords:

Regulation of gene expression
Caco-2
Fc receptor
Neonatal Fc receptor
Immunology
Transcytosis
Molecular biology
Monoclonal antibody
Epithelium
Immunoglobulin G
Biology
pharmacology toxicology
non human primate

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