The sun always rises on pride. Interview by Mark McGarry.

: Adherence is vital for HIV combination therapy. To be effective, drugs must be at high enough levels in the blood. It takes a concerted effort for patients to adhere to their regimens successfully, and close interactions with their health care provider is essential. One adherence problem is that patients tend to stop taking drugs when they feel better, and asymptomatic patients often skip pills. Side effects are also frequently difficult to manage, and dosing schedules are difficult. Patients may find that using recreational drugs or alcohol interacts adversely with the prescribed medications or may find that the recreational drug use makes them neglect following their regimen. Patients are urged to develop support networks and try various strategies to increase their chances of adhering to their treatment. A checklist of questions to consider before beginning combination therapy is included.