Primary Resistance to Ara-C in AML Progenitor Cells and its Modulation by Cytokines

An assay for the cytotoxicity of cytosine arabinoside (ara-C) for AML progenitors was validated by correlation of the median cytotoxic dose measured in vitro, D50[ara-C], with the reduction of AML blasts ≤ 5% in the bone marrow after 1 cycle of induction chemotherapy (TAD9).