FORMULATION OF SUSPENDING VEHICLES FOR EXTEMPORANEOUS ORAL LIQUID COMPOUNDING WITH DILTIAZEM HYDROCHLORIDE AS A DRUG MODEL

Objective: This study aimed to determine the optimum concentrations of a suspending vehicle and develop a physically and chemically stableformulation containing diltiazem hydrochloride (DTZ).Methods: Stability testing was performed for 30 days in selected suspending vehicle formulas (Formulas A and E). Physical stability tests wereperformed at room temperature, and physical properties (odor and color) and pH values of suspensions were evaluated.Results: The oral suspensions of DTZ were white and had a drug-like odor, and the pH had significantly decreased during storage. Chemical stabilitytests of suspensions were performed at room temperature and 4°C±2°C using ultraviolet-visible spectrophotometry.Conclusion: The concentrations of DTZ in oral suspensions fluctuated during the storage period, suggesting that the oral suspensions of DTZ arephysically stable but not chemically stable during storage.