SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL SCHIFF AND MANNICH BASES OF ISATIN Original Article

Objective: Synthesis and antimicrobial evaluation of some novel Schiff and Mannich bases of Isatin. Methods: A series of novel Schiff bases of Isatin (V) and (X) were synthesized by refluxing Isatin with p-amino ethyl benzoate (IV) and 4-(4!-amino phenyl)-6-substituted phenyl pyrimidine-2-thiol (IX). Mannich bases of ethyl-4-(2-oxindolin-3-ylidene amino) benzoate (VI) were synthesized by using various aromatic secondary amines. The chemical structures of synthesized compounds were confirmed by IR, 1 Results: The results of antibacterial and antifungal activities showed that some of the synthesized compounds were exhibited promising antimicrobial activities. HNMR, Mass and elemental