ANTIOXIDANT ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF SOME SELECTED HETEROARYL SUBSTITUTED COUMARINS

Summary Significant amounts of Coumarins, with benzopyrone ring units, are frequently present in plants. Simple coumarins and analogues are a large class of compounds with a wide spectrum of biological activity. Several series of coumarin derivatives were synthesized and five of the 5-(substituted phenyl)-1-phenyl- 2-pyrozoline-3″-yl) 6-halogen substituted coumarins were tested for in vivo analgesic and antiinflammatory studies. The compounds were selected on the basis of log P values and in vitro radical scavenging activities. Antiinflammatory activity was determined by carrageenan induced rat paw edema and analgesic activity was assessed by inhibition of hyperalgesia produced by carrageenan induced inflammation in the same rats by measuring the paw withdrawal latency. All compounds tested pharmacologically showed good analgesic and antiinflammatory activity in Wistar rats. The radical scavenging property may be one of the probable reasons for their analgesic and antiinflammatory activity.