Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication
2014
Protein modification by small ubiquitin-related modifier (SUMO) proteins is associated with antiviral responses. Here, the authors show that interferons increase the level of expression of SUMO proteins via a let-7 microRNA-controlled mechanism, and this contributes to the antiviral effects of interferons.
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