100 COMBINATION OF CALCINEURIN INHIBITORS AND GENOTYPES AT THE IL12A LOCUS INFLUENCES RISK OF RECURRENT PRIMARY BILIARY CIRRHOSIS AFTER LIVER TRANSPLANTATION

Results: Complete data were available for 1370 PBC patients, including 70 LT recipients. Median follow-up was 72.2 months. Cox regression showed that survival was best predicted by the Paris I criteria (HR=8.4; P = 5.10E-12); these criteria were used to define treatment response in subsequent analyses. Overall, 75% of patients responded to UDCA. Multivariate analysis showed that treatment response was predicted by female sex, older age, increased creatinine, lower bilirubin, lower alkaline phosphatase and the absence of splenomegaly at baseline (Table 1).