CircRNA expression profile and circRNA-miRNA-mRNA crosstalk in allergic rhinitis

CircRNA expression profile and circRNA-miRNA-mRNA crosstalk in allergic rhinitisTo the Editor,Allergic rhinitis (AR) is a chronic multi-factorial inflammatory disease, with a prevalence on the rise in China1. CircRNAs, a newly discovered family of endogenous non-coding RNAs, function in various biological processes2. For instance, circRNAs are involved in neuronal activities, tumor development, and innate immune responses, inflammatory diseases3-4. However, the roles of circRNAs in AR remain unclear. In this study, using high-throughput sequencing (HTS), we explored the circRNA, miRNA, and mRNA expression profiles in nasal mucosa from AR patients, and constructed a differentially expressed (DE) circRNA-DEmiRNA-DEmRNA network to illustrate the molecular mechanism in AR.This study was approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University and each patient provided written informed consent. Patients and methods are detailed as online data.