Investigation of amine and polyol functionality in extracts of polyurethane wound management dressings using MALDI-MS
2000
Polyurethane (PU) foams used in wound management are produced
by a reaction between aromatic diisocyanates and polyether polyols. There
is concern that residues of these starting materials, which may contain
aromatic amine functionality, may leach from the finished polymer during
in vivo applications. Furthermore, oligomers and additives may be
leached from the PU system after the polymerization process is complete.
Finished polymers have, therefore, been extracted with a range of solvents,
such as water, diethyl ether and dilute HCl. The extracts were subjected to
MALDI-MS (matrix-assisted laser desorption ionization mass spectrometry)
analysis in an attempt to determine the amine and polyol functionality.
Direct MALDI-MS analysis of the wound dressing extracts indicated the
presence of the polyol used in the formulation of the foam. The spacing
between the peaks identified the base monomer used in the polyol. MALDI-MS
analysis of the fluorescamine derivatives of model amine compounds has
demonstrated the anticipated increase in mass (278 for monoamines and 278
and 556 for diamines). Similar results were obtained from the
derivatization of model polyols with phenyl isocyanate, where the mass
shift (n × 119) was a direct measure of the number of active
hydroxyl groups. Fluorescamine labelling of PU foam extracts shows the
colour change indicative of the presence of an amine, but the subsequent
MALDI-MS analysis was unable to demonstrate the anticipated increase in
mass.
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