In vitro phase I- and phase II-drug metabolism in the liver of juvenile and adult Göttingen minipigs

Purpose In view of pediatric drug development, juvenile animal studies are gaining importance. However, data on drug metabolizing capacities of juvenile animals are scarce, especially in non-rodent species. Therefore, we aimed to characterize the in vitro biotransformation of four human CYP450 substrates and one UGT substrate in the livers of developing Gottingen minipigs.