[Meta-analysis of the association between the short-term exposure to fine particular matter and the morbidity of ischemic heart disease].

Objective Using Meta-analysis to evaluate the association between the short-term exposure to fine particular matter (PM2.5) and the morbidity of ischemic heart disease (IHD). Methods In this paper, "particulate matter" , "PM2.5" , "ischemic heart disease" , "coronary heart disease" , "coronary artery disease" , "atherosclerotic heart disease" , and "atherosclerotic cardiovascular disease" were used to systematically search for the literature on the association between the short-term exposure to PM2.5 and the ischemic heart disease through China Biology Medicine disc (CBMdisc), China National Knowledge Infrastructure (CNKI), Wanfang, Vip as well as Pubmed and Web of Science. The time was up to January 31st 2019. The quality of literature was evaluated by the Newcastle-Ottawa Scale. Meta-analysis method was performed by using R3.5.0 software and was used to perform heterogeneity test, calculate combined risk of IHD with short-term exposure to PM2.5 and carry out publication bias test. Results A total of 1 424 literatures were retrieved. Of the 23 literatures included studies (2 literatures in Chinese and 21 literatures in English) according to the inclusion and exclusion criteria, 14 used a time-series design and 9 used a case-crossover design. The heterogeneity existed across all identified studies (I2=81%, P<0.05). The Random effect model showed that a 10 μg/m3 increase in PM2.5 was associated with estimated relative risk of IHD morbidity at 1.007 (95%CI: 1.005-1.009); Publication bias was noted in the analysis (t=2.76, P<0.05), and the combined effect values of IHD morbidity was reduced to 1.005(95%CI: 1.004-1.007) after adjusting for asymmetry. Conclusion Short-term exposure to PM2.5 may lead to the increase of ischemic heart disease morbidity. Key words: Particulate matter; Myocardial ischemia; Meta-analysis