Photodynamic therapy stimulates anti-tumor immune response in mouse models: the role of regulatory Tcells, anti-tumor antibodies, and immune attacks on brain metastases
2013
We have previously shown that photodynamic therapy mediated by a vascular regimen of benzoporphyrin derivative
and 690nm light is capable of inducing a robust immune response in the mouse CT26.CL25 tumor model that
contains a tumor-rejection antigen, beta-galactosidase (β-gal). For the first time we show that PDT can stimulate the
production of serum IgG antibodies against the β-gal antigen. It is known that a common cause of death from
cancer, particularly lung cancer, is brain metastases; especially the inoperable ones that do not respond to traditional
cytotoxic therapies either. We asked whether PDT of a primary tumor could stimulate immune response that could
attack the distant brain metastases. We have developed a mouse model of generating brain metastases by injecting
CT26.CL25 tumor cells into the brain as well as injecting the same cancer cells under the skin at the same time.
When the subcutaneous tumor was treated with PDT, we observed a survival advantage compared to mice that had
untreated brain metastases alone.
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