Association of Bleeding and In-Hospital Mortality in Black and White Patients With ST-Segment–Elevation Myocardial Infarction Receiving Reperfusion

Background—Prior studies have suggested that blacks with acute ST-segment–elevation myocardial infarction have increased bleeding risks with fibrinolysis relative to whites, yet these data were quite limited. Additionally, it is unknown whether there are racial differences in bleeding risks among patients with ST-segment–elevation myocardial infarction receiving primary percutaneous coronary intervention. Methods and Results—We evaluated data on blacks and whites with ST-segment–elevation myocardial infarction treated with either fibrinolysis or primary percutaneous coronary intervention from the National Registry of Myocardial Infarction (NRMI)-4 and 5 participating centers between July 2000 and December 2006. We compared differences between the 2 groups in rates of in-hospital major bleeding and mortality, adjusted with logistic regression analyses. In fibrinolytic-treated patients with ST-segment–elevation myocardial infarction, the bleeding rates were higher among blacks (n=2283) than whites (n=42 243...