SYNTHESIS OF 3H-CYCLOALKANOPROGESTERONES (PREGNA-D'-PENTARANES) AND STUDY OF THEIR INTERACTION WITH A PROGESTERONE RECEPTOR

In order to search target organs and to study the mechanism of the action of steroids with separated biological functions, tritium-labeled pregna-d'-pentaranes were synthesized by an original procedure, and their interaction with a progesterone receptor was investigated. The uterine progesterone receptor was shown to be the only specific binding protein for these compounds.