AKT regulation of mesothelial-to-mesenchymal transition in peritoneal dialysis is modulated by Smurf2 and deubiquitinating enzyme USP4.

Li Xiao,Xiang Peng,Fuyou Liu,Chengyuan Tang,Chun Hu,Xiaoxuan Xu,Ming Wang,Ying Luo,Shikun Yang,Panai Song,Ping Xiao,Yashpal S. Kanwar,Lin Sun

AKT regulation of mesothelial-to-mesenchymal transition in peritoneal dialysis is modulated by Smurf2 and deubiquitinating enzyme USP4.

2015

Li Xiao
Xiang Peng
Fuyou Liu
Chengyuan Tang
Chun Hu
Xiaoxuan Xu
Ming Wang
Ying Luo
Shikun Yang
Panai Song
Ping Xiao
Yashpal S. Kanwar
Lin Sun

Background Transforming growth factor-β1 (TGF-β1) plays a key role in mesothelial-to-mesenchymal transition (MMT) during peritoneal dialysis (PD). However, the role of Akt in MMT transformation in PD is not clear.

Keywords:

Peritoneum
Cell biology
Vimentin
Biology
Protein kinase B
Deubiquitinating enzyme
Mesenchymal stem cell
Epithelial–mesenchymal transition
Peritoneal dialysis
Downregulation and upregulation
Mothers against decapentaplegic homolog 7
Phosphorylation
PI3K/AKT/mTOR pathway
Transforming growth factor

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