Regulation of Gonad Morphogenesis in Drosophila Melanogaster by Broad Complex, Tramtrack and Bric à Brac Transcription Factors
2016
During embryogenesis, primordial
germ cells (PGCs) and somatic gonadal precursor cells (SGPs)
migrate and coalesce to form the early gonad. A failure of SGPs and
PGCs to form a gonad with the proper architecture not only affects
germ cell development, but also can result in infertility. We have
characterized the phenotypes of two genes, longitudinals lacking
(lola) and ribbon (rib), required for the coalescence and
compaction of the embryonic gonad in Drosophila melanogaster. Both
rib and lola are expressed in the SGPs and to a lesser extent in
the PGCs of the developing gonad, and genetic interaction analysis
suggests these proteins cooperate to regulate gonad development.
Analysis of colocalization with marks of transcriptional activation
and repression on polytene chromsomes reveals that Rib and Lola
colocalize with both marks. Thus, these studies demonstrate that
Rib and Lola function cooperatively to regulate transcription of
target genes and thereby promote embryonic gonad
morphogenesis.
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