Rabbit Ciliary Process Responses to Different Routes of Water-Soluble Marihuana-Derived Material Administration

AbstractThe pharmacologic and morphologic effects of water-soluble marihuana-derived material (MDM) were examined in rabbits after different routes of administration. Subcutaneous (SC) MDM alone caused little change in intraocular pressure (IOP) yet significantly antagonized subsequent intravenous (IV) or intravitreal (IVT) MDM injections; this occurred despite the failure of SC MDM alone to induce morphological changes in the ciliary processes. Morphologic effects are usually associated with a pharmacologic response. IV MDM alone induced a large IOP fall that accompanied substantial morphologic changes; further IV MDM was ineffective in causing a change in IOP until 4 or 5 days after the initial injection. IVT MDM after IV MDM caused a fall in IOP with additional morphologic effects. IVT MDM alone caused marked pharmacologic and morphologic changes, and IV MDM after IVT MDM caused additional morphologic changes that accompanied an IOP fall. IVT injections, after a prior IVT injection, were pharmacologica...